Translational Research Programs
Working to gain an insight into the mechanisms driving tumorigenesis, drug resistance, metastasis, and to develop personalized targeted therapies and precision medicine to treat both drug resistance and metastasis.
Working to develop rapid diagnostic methods for the determination of synergy or antagonism between two or more antimicrobial agents against multi-drug resistant bacteria and fungi.
Working to identify novel and innovative approaches to diagnose and treat diseases of the nervous system.
Working to (1) Increase recipient access to orthotopic liver transplantation (OLT) through identification and targeting critical mediators of tissue damage caused by ischemia/reperfusion (I/R) injury. (2) Identify (a) diagnostic biomarkers in hepatocellular carcinoma (HCC) for patients at high risk for metastasis and (b) HCC-mutation profiles which can predict therapeutic susceptibility and limit risk of recurrence after OLT.
Working to understand the mechanisms involved in atherosclerotic plaque rupture because this is a critical barrier to developing new therapies for the prevention of carotid-related stroke and myocardial infarction (MI), both of which are complications of atherosclerosis.
Working to identify novel therapeutic targets in diabetic kidney disease using gene based strategies.