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The purpose of this study is to evaluate Orbital Atherectomy compared to conventional balloon angioplasty technique prior to stent implantation for treatment of severely calcified…

EARLY TAVR (Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patien

The purpose of this study is to evaluate the TAVR compared to surveillance for patients with asymptomatic severe aortic stenosis.

Brady MRI PAS (SJM Brady MRI Post Approval Study)

The purpose of this study is to evaluate the long-term safety of the FDA approved St. Jude Medical Tendril MRI lead implanted with a SJM…

PARADISE-MI (Prospective ARNI vs ACE Inhibitor Trial to Determine Superiority in Reducing Heart Fail

The purpose of this study is to evaluate the efficacy and safety of LCZ696 titrated to a target dose of 200 mg twice daily, compared…

MOMENTUM 3 (Momentum 3 CAP Continued Access Protocol)

The objective of the study is to continue to evaluate safety and clinical performance of the HM3 LVAS for the treatment of advanced, refractory, left…

ELITE (Eliminate Thombroembolism: Improving Anticoagulation in Non-valvular Atrial Fibrillation Pati

This study is a 2 year research project to assess warfarin management issues faced by atrial fibrillation patients in ambulatory settings.

Renal Cell Carcinoma and the effects of Perioperative Nivolumab vs. Observation in Patients

This randomized phase III trial compares nephrectomy (surgery to remove a kidney or part of a kidney) with or without nivolumab in treating patients with…

Clear Cell Renal Cell Carcinoma and the effects of CB-839 with Everolimus (CBE)

Phase 2 Study Comparing CB-839 with Everolimus (CBE) vs. Placebo with Everolimus (PboE) in Patients with Advanced or Metastatic RCC. Click here to download the…

Small Cell Lung Cancer and the effects of Rovalpituzumab Tesirine Compared With Topotecan

The purpose of this randomized, open-label, 2-arm, Phase 3 study is to assess the assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan…

Small Cell Lung Cancer (SCLC) and the effects of Rovalpituzumab tesirine/dexamthasone

This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based…