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Medial meniscus deficiency and the effects of the NUsurface Meniscus Implant

The purpose of this study is to evaluate the safety and clinical benefit of a new artificial meniscus implant to treat patients with knee pain…

Symptomatic Chondral or Osteochondral Defects of the Knee and the effects of MACI

The purpose of this study is to evaluate the safety and performance of MACI compared to microfracture in children aged 10-16years old. MACI is an…

Cisplatin, Intensity-Modulated RT, and Pembrolizumab for Stage III-IV Head and Neck Cancer

This phase I trial studies the side effects and best dose of Pembrolizumab when given together with Cisplatin and intensity-modulated radiation therapy, in treating patients…

NKTR-214 with Anti-PD-1 OR Anti-PD-L1 for Select Advanced or Metastatic Solid Tumors (PROPEL)

This study is to assess the safety and tolerability, define the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) and to assess the…

AG-120 (Ivosidenib) vs. Placebo with Azacitidine for Previously Untreated AML with IDH1 Mutation

Study AG120-C-009 is a global, Phase 3, multicenter, double-blind, randomized, placebo-controlled clinical trial to evaluate the efficacy and safety of AG-120 (Ivosidenib) + Azacitidine vs…

Expressing Personalized Tumor Antigens Study (NEO)

This is a Phase 1, open-label, uncontrolled, multicenter study in 3 distinct solid tumors. The study design is dose-escalation/de-escalation using a standard 3 + 3…

Hypofractionated RT after Mastectomy in Preventing Recurrence in Stage IIa-IIIa Breast Cancer

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with Stage IIa-IIIa Breast Cancer who have undergone…

Pembrolizumab +/- Stereotactic Body Radiation Therapy for Advanced Merkel Cell Cancer

This randomized phase II trial studies how well Pembrolizumab with or without stereotactic body radiation therapy works in treating patients with Merkel Cell Cancer that…

Articular Cartilage Defects and the effects of NOVOCART 3D vs Microfracture

NOVOCART 3D is a surgical procedure completed in two steps. This procedure utilizes your own cartilage in the repair of your knee. Microfracture is a…

Carvedilol in Preventing Cardiac Toxicity in Patients with Metastatic HER-2-Positive Breast Cancer

This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that…