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Rucaparib vs. Physician’s Choice in Metastatic CRPC & Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to…

Rucaparib for Metastatic CR Prostate Cancer & Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to…

Intra-arterial Gemcitabine vs. IV Gemcitabine + Nab-Paclitaxel after RT for LAPC (TIGeR-PaC)

The study is a multi-center, un-blinded, randomized control study of subjects with locally advanced pancreatic adenocarcinoma which is unresectable. Click here to download the Fast…

International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) (InPACT)

This is an international phase III trial, with a Bayesian design, incorporating two sequential randomizations. It efficiently examines a series of questions that routinely arise…

Osimertinib in Treating Stage IIIB-IV or Recurrent NSCLC with EGFR Exon 20 Insertion Mutations

This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is…

Cisplatin/Carboplatin & Etoposide +/- Nivolumab in Patients with Extensive Stage Lung Cancer

This randomized phase II clinical trial studies how well cisplatin, carboplatin, and etoposide work when given together with nivolumab in treating patients with extensive stage…

Nivolumab, Cabozantinib S-Malate, and Ipilimumab in Treating Patients with Recurrent Stage IV NSCLC

This partially randomized phase II trial studies how well nivolumab, cabozantinib s-malate, and ipilimumab work in treating patients with stage IV non-small cell lung cancer…

A Phase 1 Study of BLU-554 in Patients with Hepatocellular Carcinoma

This is a Phase 1, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of BLU-…

Rucaparib in Patients with Locally Advanced or Metastatic Urothelial Carcinoma (ATLAS)

The purpose of the ATLAS study is to determine how patients with locally advanced or metastatic urothelial carcinoma respond to treatment with rucaparib. Click here…

PATINA: Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer

The primary objective of this study is to demonstrate that the combination of palbociclib with anti-HER2 therapy plus endocrine therapy is superior to anti-HER2-based therapy…