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Metastatic Pancreatic Cancer and the effects of 2nd Line FOLFIRI Versus Modified FOLFIRI with PARP

This randomized phase II trial studies how well modified irinotecan hydrochloride, leucovorin calcium, fluorouracil (FOLFIRI), and veliparib as a second line of therapy work compared…

Metastatic Pancreatic Cancer and the effects of BL-8040 and Pembrolizumab

This study will assess the efficacy and safety of BL-8040 as a single agent and in combination with Pembrolizumab (Keytruda) in subjects with metastatic pancreatic…

Non-Small Cell Lung Cancer and the effects of Atezolizumab alone vs with Daratumumab

The purpose of the study is to compare the overall response rate in Non-Small Cell Lung Cancer (NSCLC) participants treated with Daratumumab in combination with…

Medical Oncology and the effects of Anetumab Ravtansine in Combination with Pemetrexed and Cisplatin

Determine the safety, tolerability and maximum tolerated dose of anetumab ravtansine (BAY 949343) in combination with pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 in subjects…

Metastatic Sarcoma and the effects of MLN0128 (TAK-228) vs. Pazopanib

This partially randomized phase I/II trial studies the side effects and best dose of sapanisertib and to see how well it works compared to pazopanib…

Ovarian Cancer and the effects of Niraparib Maintenance Treatment

This study is a double-blind, randomized, placebo-controlled (2:1 niraparib:placebo) study in patients with Stage III or IV ovarian cancer. Patients must have completed frontline platinum…

Renal Cell Carcinoma and the effects of Multiple MET Kinase Inhibitors

This randomized phase II trial studies how well cabozantinib-s-malate, crizotinib, volitinib, or sunitinib malate work in treating patients with kidney cancer that has spread from…

Renal Cell Carcinoma and the effects of Pembrolizumab combined with Axitinib Versus Sunitinib

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) in combination with axitinib versus sunitinib monotherapy as a first-line…

Solitary Osseous Plasmacytoma and the effects of Adjuvant Systemic Treatment and Zoledronic Acid

This randomized phase III trial compares ixazomib citrate, lenalidomide, dexamethasone, and zoledronic acid with zoledronic acid alone to see how well they work when given…

Bladder Cancer and the effects of Intravesical Therapy

This randomized phase III trial studies Tokyo-172 strain bacillus Calmette-Guerin (BCG) solution with or without a vaccination using Tokyo-172 strain BCG to see how well…